‘Smart’ surgical scalpel detects uterine cancer ‘within seconds’, study finds

‘Smart’ surgical scalpel detects uterine cancer ‘within seconds’, study finds

‘Smart’ surgical scalpel detects uterine cancer ‘within seconds’, study finds

Scientists have shown that a smart surgical knife that can detect when it cuts through cancerous tissue “reliably” diagnoses uterine cancer “in a matter of seconds.”

The research, published in the journal Cancers, is expected to minimize the current delays for women waiting for a diagnosis of uterine cancer after their tissue samples are analyzed in laboratories.

The device, iKnife, has shown in previous studies to be a revolutionary tool in the diagnosis of different types of cancer that can indicate exactly what tissue to remove from a patient, reducing surgery time and the need for repeat operations.

Previous studies have shown that the smart “smart” scalpel, a type of electrosurgical scalpel used to cut and cauterize blood vessels, can correctly identify different types of tissue, including lung, colon and liver.

Research has shown that the iKnife works by drawing smoke during cauterization into a mass spectrometer, a device that reads chemical signatures and indicates whether the cut tissue is cancerous or healthy.

“The iKnife is an emerging tool that uses standard electrosurgical methods to generate surgical aerosols that are then interrogated by a mass spectrometer to provide real-time tissue signatures,” the scientists, including those from Imperial College London, explained in the study.

In the new research, the scientists sought to determine if the iKnife can correctly identify endometrial cancer from biopsy samples.

Endometrial cancer is a common gynecological cancer with more than 120,000 new cases diagnosed per year in the European Union alone, say scientists.

The researchers evaluated about 150 endometrial samples in this study and found that the smart scalpel “reliably” diagnosed endometrial cancer in seconds, with a diagnostic accuracy of about 90 percent.

“These results are very encouraging and suggest that the iKnife could be used in the clinic to provide point-of-care diagnosis,” the scientists noted, adding that the surgical tool may pave the way for “new diagnostic avenues.”

So far, the researchers say, analysis of tissue samples for the diagnosis of uterine cancer can “take up to two weeks” and delays in treatment and definitive surgery have been shown to negatively impact chances of survival. .

With the iKnife, which has been shown to “precisely discriminate” between normal and cancerous tissue in various tumors, including colon, breast, cervical and ovarian tissue, the researchers say a rapid diagnostic method may be developed. at the point of care for endometrial cancer.

They say smart scalpel technology “has the potential to speed up the patient journey, providing point-of-care diagnosis for women with suspected endometrial cancer.”

“It accurately distinguishes normal from malignant endometrial tissue based on differences in their lipidomic profiles. Further larger studies are needed to validate this technique and improve its diagnostic performance,” the scientists added.

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